Computational Biology Platform
Talindrew is a browser-native molecular biology platform. Design. Clone. Fold.
Discover in one tab.
Talindrew unifies sequence editing, cloning design, restriction analysis, protein structure prediction, and AI-assisted drug discovery in a single browser tab, with no software to install.
Biologists shouldn't need six browser tabs to run a single experiment.
Four tools, one experiment.
Sequence visualization, cloning design, BLAST, and protein folding each live in a different tab. Every context switch costs time you don't have.
Copy-paste is error-prone.
Manually transferring sequences between tools silently introduces mutations. There's no diff. No audit trail. No way to know when it went wrong.
Results go missing.
Outputs scatter across downloads, emails, and browser tabs. Reproducing a workflow from last week becomes archaeology.
Six ways in.
One finished plasmid out.
EGFP head into the pUC19 MCS, cut EcoRI / BamHI and ligated directionally.
Inputs
pUC19 MCS
2,686 bp · circular
EGFP head
180 bp · linear
Product
pUC19 MCS + EGFP head
2,839 bp
- EGFP head2–176
- pUC19 MCS176–2,839
Reaction
- Enzymes
- EcoRI · BamHI
- Directional
- Yes
- Cut sites found
- 2
- Product
- 2,839 bp
Protocol
- 1Digest vector (2686 bp) with EcoRI and BamHI at 37C for 1-2 hours
- 2Digest insert (180 bp) with EcoRI and BamHI at 37C for 1-2 hours
- 3Run digests on agarose gel and purify correct fragments
- 4Set up ligation: 50-100 ng vector, 3:1 molar ratio insert:vector
Load demo → Next → Create product. No sequences of your own required.
Everything you need,
in one tab.
One unified workspace.
Sequence editor, cloning designer, BLAST, and protein folding — all in one tab.
Live analysis.
Digest, primer design, and structure prediction update as you edit.
AI-assisted design.
An AI assistant that understands your sequence and speeds up decisions.
Platform
01 / Sequence Editor
See your sequence the way it should be seen.
Load GenBank, FASTA, SnapGene, or raw text. Get a zoomable circular and linear map, base-by-base view, and a full annotation table.
02 / Cloning Design
Design your strategy in minutes.
Six guided wizards: Gibson, Golden Gate, Restriction, Gateway, TOPO, and SDM — each with a visual node graph.
INSERT
03 / Analysis Suite
Every tool, already open.
BLAST, restriction digest, oligo calculator, gel simulator — one click away, in context with your sequence.
04 / FoldRx
From sequence to drug candidate.
An automated 8-stage pipeline: fold → detect pockets → dock ligands → ADMET → FEP → rank candidates. No HPC required.
1
Fold
2
Pockets
3
Dock
4
ADMET
5
FEP
6
Rank
Ask anything.
Get biology back.
Your sequences, explained. Ask about annotations, cloning strategies, or protocol generation.
I found 3 restriction sites in your GFP coding sequence:
Would you like me to design a cloning strategy using these sites?
Frequently asked questions
- What is Talindrew?
- Talindrew is a browser-native molecular biology platform that lets researchers edit DNA sequences, design cloning strategies, run restriction and gel simulations, predict protein structures, and screen drug candidates in a single tab. There is nothing to install and it runs on any modern browser, including on a Chromebook.
- Is Talindrew free to use?
- Yes. Talindrew is free to start, with no credit card and no account required to try the editor. The free tier covers the sequence editor, cloning wizards, restriction analysis, BLAST search and the AI assistant.
- What cloning methods does Talindrew support?
- Talindrew simulates eight cloning strategies against a real digest-and-ligate engine: restriction cloning, Gibson Assembly, Golden Gate, Gateway, TOPO and TA, In-Fusion and NEBuilder HiFi, and site-directed mutagenesis. Six of them have a guided wizard with a worked example; the rest run from the node-graph designer.
- Can Talindrew open SnapGene and GenBank files?
- Yes. Talindrew imports GenBank (.gb, .gbk), FASTA, EMBL, ApE (.ape) and SnapGene (.dna) files, including their features and primers, plus Sanger traces in AB1, SCF and ZTR format and annotation tracks in BED, GFF3 and GTF. It exports GenBank and FASTA, and maps as SVG, PNG, PDF or DOCX.
- How does Talindrew predict protein structures?
- Talindrew runs ESMFold on GPU and returns a pLDDT-scored 3D model in seconds, with no local GPU or Python environment required. Structures with high confidence feed automatically into the FoldRx drug discovery pipeline for pocket detection and docking.
- What is the FoldRx pipeline?
- FoldRx is an eight-stage automated drug discovery pipeline: sequence input, protein folding with ESMFold, binding pocket detection with Fpocket, ligand docking with AutoDock Vina, ADMET screening, free energy perturbation scoring, selectivity profiling against anti-targets, and a weighted composite ranking you can export as CSV.
- How does Talindrew compare to SnapGene and Benchling?
- SnapGene is a desktop application with a free viewer mode and paid editing; Benchling is an enterprise R&D platform with a free academic tier and a full electronic lab notebook. Talindrew is free to start in the browser and adds protein structure prediction and drug discovery, but has no lab notebook, no sample registry and no multiple sequence alignment.
/ Get Started
Your entire molecular biology
workflow, in one window.
No downloads. No plugins. No spreadsheets of sequences. Start with any of 12 built-in example sequences and run the full workflow in under 10 minutes.
Open Talindrew