Talindrew is a molecular biology platform that runs in your browser. Design Clone Fold
Discover in one tab
Talindrew unifies sequence editing, cloning design, primer design, sequencing verification, restriction analysis, multiple sequence alignment, protein structure prediction, and drug discovery with AI in a single browser tab, with no software to install.
Free plan, no credit card
Used by researchers at
KAUST
University of Brescia
NISER
What slows an experiment down
Four tools, one experiment
Sequence visualization, cloning design, BLAST, and protein folding each live in a different tab. Every context switch costs time you don't have.
Copying and pasting invites errors
Manually transferring sequences between tools silently introduces mutations. There's no diff. No audit trail. No way to know when it went wrong.
Results go missing
Outputs scatter across downloads, emails, and browser tabs. Reproducing a workflow from last week becomes archaeology.
One workbench for the whole experiment
Edit the sequence, design the clone, check it on a gel and screen drugs against the protein, in one tab. These are the real views, drawn from real data.
Sequence Editor
See your sequence the way it should be seen.
Load GenBank, FASTA, SnapGene, or raw text. Get a zoomable circular and linear map, a view of every base, and a full annotation table.
Cloning Design
Design your strategy in minutes.
Six guided wizards: Gibson, Golden Gate, Restriction, Gateway, TOPO, and SDM. Plus a cloning workspace that reads and writes OpenCloning strategy files.
Analysis Suite
Every tool, already open.
Primer design, multiple sequence alignment, BLAST, restriction digest, gel simulator: one click away, in context with your sequence.
FoldRx
From sequence to drug candidate.
A visual pipeline: fold, detect pockets, dock ligands, ADMET, pose checks, selectivity, rank and design analogs. No HPC required.
Ask anything
and get biology back
Your sequences, explained. Ask about annotations, cloning strategies, or protocol generation.
I found 3 restriction sites in your GFP coding sequence:
Would you like me to design a cloning strategy using these sites?
The full walkthrough
Every part of Talindrew in one sitting, from importing a sequence to cloning, primers, alignment and the notebook. 17 min long, for when you want the whole picture.
Open the video pageFrequently asked questions
Talindrew is a molecular biology platform in the browser that lets researchers edit DNA sequences, design cloning strategies in guided wizards or an OpenCloning compatible cloning workspace, design PCR primers, verify clones from Sanger traces, align multiple sequences, run restriction and gel simulations, predict protein structures, and screen drug candidates in a single tab. There is nothing to install and it runs on any modern browser, including on a Chromebook.
For cloning work, yes. Talindrew runs in the browser and its sequence editor, plasmid maps, cloning simulation (Gibson, Golden Gate, restriction, Gateway and more), PCR primer design, multiple sequence alignment, gel simulation and lab notebook are free with a Google sign-in, with nothing to install. It opens SnapGene .dna files with their features, primers and cloning history, and saves OpenCloning strategies. Two honest limits: it exports GenBank and FASTA rather than writing .dna files back out, and hosted protein folding starts on the Pro plan. Tables comparing them are on the Talindrew vs SnapGene and Talindrew vs Benchling pages.
Yes. Talindrew is free to start, with no credit card and no procurement. Sign in with Google and the whole cloning workbench is there: the sequence editor, cloning wizards, primer design, multiple sequence alignment, restriction analysis, gel simulation, BLAST search and the lab notebook. The biomath calculators run in the browser with no sign-in at all. Protein folding, drug discovery runs and the AI assistant use paid compute and start on the Pro plan.
The Free plan costs nothing and covers the sequence editor, every cloning strategy, primer design, alignment, CRISPR guide design, gel simulation and the lab notebook. Pro is $24 a month, or $240 a year, and adds protein structure prediction, 10 drug discovery runs a month and the AI assistant. Max is $99 a month, or $990 a year, with 50 drug discovery runs and 300 structure predictions a month. Verified academics pay $15 for Pro and $69 for Max. Full details are on the pricing page.
Talindrew simulates eight cloning strategies against a real digest and ligate engine: restriction cloning, Gibson Assembly, Golden Gate, Gateway, TOPO and TA, In-Fusion and NEBuilder HiFi, and site-directed mutagenesis. Six of them have a guided wizard with a worked example; the rest run from the node graph designer. A separate cloning workspace, a port of OpenCloning running the pydna engine, adds sixteen operations on one node graph: restriction digest, PCR, oligonucleotide hybridisation, polymerase extension, reverse complement, annotation, Gibson, In-Fusion, In vivo and overlap extension assembly, restriction and ligation, ligation, homologous recombination, CRISPR HDR, Gateway BP and LR, Cre/Lox and recombinases with custom sites.
Start designing today.
Open to every scientist, academic or commercial. The whole cloning suite, protein folding and drug discovery â in any browser, nothing to install.
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