Changelog

What shipped in Talindrew, and when. Each entry is dated by the commit that landed it; nothing here is planned or in progress.

Last updated 6 Sep 2026.

1. 6 Sep 2026Primers

   PCR primer design

   A primer designer over any selected region of a sequence, plus an Oligos tab that is the construct's own primer library. The engine runs client-side, so the ranked candidate list re-ranks as the constraints move.

   • Per-primer scoring on Tm, GC content, length, 3′ GC clamp, homopolymer runs, hairpins, self- and 3′-anchored dimers and binding-site count; pairs scored on ΔTm, cross-dimers and product size.
   • Every Tm is the same nearest-neighbour value the Melting Temperature calculator uses, so the two cannot disagree.
   • Binding-site search on both strands with amplicon prediction, including products that cross the origin of a circular template.
   • 5′ overhang builder: 13 restriction sites with guard bases, Kozak, T7 promoter, His₆ tag, Gibson/HiFi homology arms or custom text; annealing Tm and full-oligo Tm reported separately.
   • Primers persist with the sequence, import from FASTA or a pasted list, export as CSV or FASTA, draw on both maps and export as primer_bind features.

   Primer design tool →

2. 6 Sep 2026Alignment

   Multiple sequence alignment

   A new Alignment workspace aligns up to 200 DNA, RNA or protein sequences. The built-in aligner is progressive: k-mer distances, a UPGMA guide tree, then profile-to-profile alignment with affine gap penalties, and MAFFT, MUSCLE and Clustal Omega are used instead when they are installed on the server.

   • Consensus row, per-column conservation track, identity-matrix heat map and a UPGMA tree built from the finished alignment.
   • Per-base colours for DNA, Clustal-X class colours for protein shaded by conservation, a differences-only mode and a click-a-column detail panel.
   • Load sequences from open tabs, a saved construct, a FASTA paste or a file; export aligned FASTA, CLUSTAL or Newick.
   • Eight 1.5 kb sequences align in well under a second; results are cached, so re-running an unchanged set costs no request.

   Multiple sequence alignment tool →

3. 5 Sep 2026Notebook

   Sample project, live maps in entries, image resizing

   Every new user now finds a seeded sample project on their first visit. Sequence blocks inside a notebook entry draw the real circular and linear maps, in the editor and in the print and shared read-only views. Images resize by dragging and keep their size everywhere the entry is rendered.

4. 4 Sep 2026Notebook

   PubMed and Europe PMC citations

   Search PubMed and Europe PMC from the browser and cite a paper straight into a notebook entry. Print exports now match the on-screen sheet in both the PDF and the Word file.

5. 3 Sep 2026Sequence editor

   SnapGene-style history and print preview

   Talindrew reads the cloning history tree out of SnapGene .dna files and records its own operations in the same model, drawn as a History tab. Click selection on the maps matches SnapGene's behaviour. A print preview of any sequence downloads as PDF or Word.

   Talindrew vs SnapGene →

6. 2 Sep 2026Notebook

   Electronic lab notebook with eLabFTW sync

   A full electronic lab notebook shipped in twelve phases: rich-text and markdown entries with equations, code and images; Talindrew blocks that save a cloning result, map, gel or trace into an entry; typed fields, templates, protocols with checklist steps and structured tables; comments, review, witness and e-signatures with timestamps; resources and inventory with storage, containers, compounds and QR labels; equipment booking with iCal export; export to PDF, ZIP, JSON, CSV and the .eln archive; and a two-way sync with eLabFTW.

   Talindrew vs Benchling →

7. 1 Sep 2026Platform

   Job queue for heavy workloads, Google sign-in

   Cloning, folding and other heavy requests run through a Redis-backed job queue with a separate worker service, so the API stays responsive and cloning no longer depends on a Temporal server. Sign-in is Google only.

8. 31 Aug 2026Calculators

   Biomath calculator suite

   Twenty-plus free calculators that run entirely in the browser: nucleic-acid mass and mole conversions, oligo Tm by four methods, ligation ratios, OD260, dilutions, molarity, qPCR efficiency, doubling time, g-force, each with its formula, citation, worked example and the reference calculator it is verified against.

   All calculators →

9. 22 Aug 2026Site

   Comparison pages, guides and tool pages

   Honest comparison pages against Benchling, SnapGene, Geneious and ApE with rows Talindrew loses; technique guides for Gibson Assembly and Golden Gate; tool pages for the restriction digest simulator and oligo Tm calculator; llms.txt for answer engines.

   All features →