The MCP server for molecular biology
Talindrew gives Claude, ChatGPT, Codex, Cursor and 17 more AI apps 90 molecular biology tools: plasmid maps, digests and gels, primers, CRISPR guides, a cloning workspace that runs the reactions, literature and your lab notebook. Ask in plain language; results come back in the chat and open in the Talindrew app. Connecting is free.
Server URL
https://mcp.talindrew.com/mcpStreamable HTTP with OAuth. Your first sign-in with Google creates a free Talindrew account.
create_workspaceWorkspace readyimport_from_repositorypUC19, 2,686 bp circularsimulate_gel3 bands: 2,364, 234 and 88 bpadd_gel_to_notebookSaved to your notebook
The request from the film, replayed: Claude calls Talindrew's tools, and the gel shows pUC19's real EcoRI and PvuII fragments.
Watch Claude and Codex use Talindrew
3.5 min, recorded on the real apps
Talindrew in Claude and Codex: clone, run gels, design CRISPR guides and screen drugs with AI
Chapters
1 min
Short on time? The same story in 77 seconds
Add the connector, ask for a digest and a gel, and see it filed in your notebook. Then a quick look at cloning, CRISPR, Sanger and drug screening in the app.
Chapters and descriptionConnect in three steps
About a minute in any app. You approve exactly what your AI app may do, and you can disconnect it any time in Talindrew's Settings.
- 1
Copy the server URL
https://mcp.talindrew.com/mcp - 2
Add it in your app
- Open Customize โ Connectors (claude.ai/customize/connectors), click + Add โ Add custom connector.
- Name it Talindrew, paste https://mcp.talindrew.com/mcp and click Add (leave authentication on โSign in nowโ).
- Click Connect, sign in with Google and click Allow. New to Talindrew? That sign-in creates your free account.
- In a chat, ask for something Talindrew does; approve the tool when Claude asks.
Signing in with Google creates your free Talindrew account the first time. No card needed.
- 3
Ask for something
Each of these is free and read-only. Claude, ChatGPT and Cursor show the results as interactive panels.
- Use Talindrew to find the restriction sites in pUC19 and show me the map.
- With Talindrew, design PCR primers for bases 100-600 of this sequence: <paste DNA>
- Ask Talindrew for the melting temperature of CGTTGTAAAACGACGGCCAGTGAAT.
Rather start in the app? Create your free account, then add the connector.
Using an AI agent? Let it set Talindrew up
Paste this into Claude Code, Codex, Cursor, VS Code, Gemini CLI, Cline or any agent that can edit its own MCP settings.
Set up the Talindrew MCP server in this app.
- Server name: talindrew
- URL: https://mcp.talindrew.com/mcp
- Transport: Streamable HTTP (remote). Authentication: OAuth; do not add any API key or header.
Use this app's own command or MCP config file (merge into the existing config; never remove other servers).
Then tell me how to start the sign-in (it opens Talindrew in my browser; signing in with Google creates a free
account). After I've signed in, call Talindrew's primer_tm tool on CGTTGTAAAACGACGGCCAGTGAAT and show the result.Every app it works with
Step-by-step setup, config files and one-click install links for every app. Signing in with Google creates a free Talindrew account the first time.
Claude (web, desktop and mobile)
Chat app ยท interactive panels ยท tested
Claude Code
Coding agent ยท text results ยท tested
Codex (CLI, IDE extension and ChatGPT desktop app)
Coding agent ยท text results ยท tested
ChatGPT
Chat app ยท interactive panels ยท tested
VS Code (GitHub Copilot)
IDE ยท panels (experimental)
Cursor
IDE ยท interactive panels
Gemini CLI and Antigravity
Terminal ยท text results
Devin Desktop (formerly Windsurf)
IDE ยท text results
Zed
IDE ยท text results
Cline
Coding agent ยท text results
Goose
Coding agent ยท panels (experimental)
opencode
Terminal ยท text results
Continue
IDE ยท text results
Kiro (successor to Amazon Q Developer)
IDE ยท text results
Warp
Terminal ยท text results
LM Studio
Chat app ยท text results
Raycast
Launcher ยท text results
Perplexity
Chat app ยท text results
Grok
Chat app ยท text results
Mistral (Le Chat / Vibe Work)
Chat app ยท text results
Microsoft Copilot Studio
Enterprise ยท text results
Gemini Enterprise
Enterprise ยท not supported yet
Claude API, OpenAI Responses API and xAI API
API ยท text results
What it can do
One question, one tool call, one answer: pUC19 cut with EcoRI and HindIII gives 2,635 and 51 bp, both with a 4-nt 5โฒ overhang. The map and the fragments come back in the conversation.
Sequence analysis
FreeThe same engines as the app. Results come back as interactive maps, gels and tables in Claude and ChatGPT.
| analyze_sequence | Length, GC, unique cutters, features and a plasmid map |
| find_restriction_sites | Enzyme sites with Dam/Dcm methylation, any of 600+ enzymes |
| digest_sequence | Fragments, overhangs and a simulated gel |
| detect_features | Promoters, origins, resistance genes and tags |
| find_orfs | Six-frame ORFs with their proteins |
| translate_dna | Protein and mRNA in any frame and genetic code |
| align_sequences | Global or local pairwise alignment (BLOSUM62 for protein) |
| simulate_gel | Band positions next to a real ladder |
Primers, CRISPR and proteins
FreeDesign and check oligos, guides and expression constructs.
| design_primers | Ranked PCR primers around a target region |
| primer_tm | Nearest-neighbour, Wallace and salt-adjusted Tm |
| mutagenesis_primers | Q5-style site-directed mutagenesis primers |
| find_crispr_guides | SpCas9 guides scored for on-target activity and off-targets |
| protein_properties | MW, pI, extinction coefficient, GRAVY, stability |
| optimize_codons | Codon optimisation for an expression host, with CAI |
| reverse_translate | Protein to DNA using a host's preferred codons |
| ligation_calculator | Insert amount for a molar insert:vector ratio |
The cloning workspace
FreeA whole cloning strategy, built reaction by reaction: the same engine the app's workspace runs, on the same OpenCloning file. Every step comes back as the canvas's own node card, and the workspace opens in the app when you want the editor.
| create_workspace | Start a cloning workspace, or open one you already have |
| import_sequence | Bring a sequence in: typed, pasted GenBank/FASTA, or an uploaded file |
| import_from_repository | AddGene, Benchling, SnapGene, Euroscarf, iGEM, WekWikGene or a genome region |
| add_cloning_step | Restriction, ligation, Gibson, Golden Gate, Gateway, PCR, recombination, CRISPR |
| design_cloning_primers | Primers for the reaction you are about to run, tails included |
| check_primers | Tm, hairpins and heterodimers before you order |
| check_sequencing | Read a trace or a FASTA against the construct it should be |
| domesticate_part | Remove internal sites and add the assembly's own overhangs |
| edit_workspace_sequence | Cut, copy, paste, flip or set the origin, on the molecule |
| list_workspace_sequences | Every step and product, as the canvas draws them |
| export_workspace | The OpenCloning JSON, GenBank or a zip of the whole strategy |
| start_from_template | A kit template or a worked example to start from |
Literature and databases
FreeLook things up without leaving the conversation.
| search_pubmed | PubMed hits with authors, journal, year and DOI |
| get_pubmed_abstracts | Abstracts for up to 20 PMIDs |
| search_europepmc | Europe PMC, including preprints and open-access full text |
| search_genes | NCBI Gene: symbol, organism, location, summary |
| search_addgene | Addgene's plasmid catalog |
Your Talindrew account
FreeRead and write your own sequences, cloning workspaces and lab notebook. Nothing is shared unless you share it in the app.
| list_my_sequences | Your saved sequences |
| save_sequence | Save a sequence (and its features) to your library |
| list_my_workspaces | Your cloning workspaces and their steps |
| create_notebook_entry | Write a lab-notebook entry, in Markdown or as blocks |
| add_sequence_to_entry | Embed a sequence map and GenBank file in an entry |
| add_cloning_step_to_notebook | File a reaction as a cloning block, with its map and plan |
| add_workspace_to_notebook | The whole strategy, one block per reaction, JSON attached |
| add_primers_to_notebook | A primer table: name, sequence, direction and Tm |
| add_gel_to_notebook | A simulated gel beside the digest that produced it |
| export_notebook_entries | PDF, Word or Markdown, as the app exports them |
| share_with | Share a sequence, workspace or entry with a colleague, or by link |
| list_notebook_entries | Search your notebook |
Structure prediction and drug discovery
Pro / MaxMetered compute on your plan's monthly allowance. On Free, the tool tells you what the run needs and offers a secure payment link.
| run_model | Boltz-2, AlphaFold 2, ESMFold, DiffDock and more from the Model Hub |
| get_model_run | Status and results of a prediction batch |
| start_foldrx_run | Fold โ pockets โ generate or screen โ dock โ rank |
| get_foldrx_run | Progress and ranked candidates |
| account_status | Your plan, usage and limits |
| start_checkout | A secure payment link to upgrade (nothing is charged until you pay) |
Frequently asked questions
Yes. Talindrew's MCP server (https://mcp.talindrew.com/mcp) gives Claude, ChatGPT, Codex, Cursor, VS Code, Gemini CLI and other MCP clients 90 molecular biology tools: plasmid maps and restriction digests, simulated gels, PCR and mutagenesis primer design, oligo Tm, CRISPR guide design, ORF finding, codon optimisation, protein properties, PubMed, Europe PMC, NCBI Gene and Addgene search, a lab notebook, structure prediction, and a full cloning workspace: restriction, ligation, Gibson, Golden Gate, Gateway and CRISPR reactions on the same OpenCloning file the app uses. It is free to connect, with OAuth sign-in.
Any MCP client that supports remote (Streamable HTTP) servers with OAuth: Claude (web, desktop, mobile), Claude Code, Codex, ChatGPT, VS Code with GitHub Copilot, Cursor, Gemini CLI and Antigravity, Devin Desktop (Windsurf), Zed, Cline, Goose, opencode, Continue, Kiro, Warp, Raycast, Perplexity, Grok, Mistral and Microsoft Copilot Studio. Each has a setup page at talindrew.com/mcp.
Connecting is free, and the free plan includes 25 tool calls a week (reset every Monday) for the sequence, primer, CRISPR, literature and notebook tools. Plus ($9/month or $99/year, with a 7-day free trial) makes tool calls unlimited. Structure prediction and FoldRx drug-discovery runs use the monthly allowance of a Pro ($24/month) or Max ($99/month) plan, exactly as in the app.
Your AI app opens Talindrew in the browser, you sign in with Google (which creates a free account the first time) and approve the connection. The app receives a token for Talindrew only, never your Google credentials. You can disconnect it any time in Settings โ Connected apps.
Claude on the web and desktop, ChatGPT and Cursor render Talindrew's results as interactive panels (MCP Apps); VS Code and Goose do so experimentally. Command-line clients such as Claude Code, Codex and Gemini CLI get the same results as text and data, with links that open each result in the Talindrew app.
Only when you ask. Tools that write say so, delete tools are marked destructive so your AI app asks before using them, and a connection can be limited to reading when you approve it.
Start free, upgrade for compute
Free includes 25 tool calls a week; Plus ($9/month) makes them unlimited. Pro and Max add structure prediction and FoldRx.